GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs3771570 | 1 | rs56052835 | chr2:242243251 | ANO7 | chr2:242127924-242164791:+ | 0.36 | 4.22 | 2.97E-5 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs56052835 | chr2:242243251 | SEPT2 | chr2:242254723-242293439:+ | -0.29 | -4.3 | 2.06E-5 | Prostate cancer |
| THCA | cis | rs7223966 | 1 | rs56057198 | chr17:61733332 | FTSJ3 | chr17:61896795-61905031:- | 0.32 | 5.58 | 3.93E-8 | Body mass index |
| THCA | cis | rs7223966 | 1 | rs56057198 | chr17:61733332 | MAP3K3 | chr17:61699775-61773669:+ | 0.26 | 5.04 | 6.65E-7 | Body mass index |
| THCA | cis | rs6978712 | 1 | rs56060721 | chr7:127148448 | GRM8 | chr7:126078652-126893147:- | -0.35 | -3.57 | 0.000398 | Medication adherence in chronic diseases |
| THCA | cis | rs73086581 | 1 | rs56069856 | chr20:3965709 | MAVS | chr20:3827449-3856761:+ | -0.22 | -3.46 | 0.000596 | Response to antidepressants in depression |
| THCA | cis | rs3105593 | 1 | rs56069965 | chr15:50966973 | SPPL2A | chr15:50999739-51057910:- | 0.28 | 7.46 | 4.1E-13 | QT interval |
| THCA | cis | rs56077333 | 1 | rs56077333 | chr15:78899003 | CHRNA5 | chr15:78857906-78886458:+ | -0.43 | -8.72 | 4.74E-17 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs6472235 | 1 | rs56080166 | chr8:66795198 | PDE7A | chr8:66629906-66753755:- | 0.16 | 3.57 | 0.000391 | Myopia (pathological) |
| THCA | cis | rs3105593 | 1 | rs56080544 | chr15:50950970 | SPPL2A | chr15:50999739-51057910:- | 0.29 | 7.51 | 2.88E-13 | QT interval |
| THCA | cis | rs8030605 | 1 | rs56083605 | chr15:56512949 | MNS1 | chr15:56720929-56757335:- | -0.23 | -3.41 | 0.000699 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs56083605 | chr15:56512949 | TEX9 | chr15:56657644-56738071:+ | -0.34 | -5.84 | 9.5E-9 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs2163813 | 1 | rs56093876 | chr19:19819115 | ZNF14 | chr19:19821281-19843921:- | 0.24 | 4.74 | 2.84E-6 | Toenail selenium levels |
| THCA | cis | rs2985684 | 1 | rs56098064 | chr14:50105849 | MGAT2 | chr14:50087489-50090198:+ | 0.22 | 4.47 | 9.67E-6 | Carotid intima media thickness |
| THCA | cis | rs2985684 | 1 | rs56098064 | chr14:50105849 | RPL36AL | chr14:50085407-50087349:- | 0.53 | 15.51 | 3.15E-44 | Carotid intima media thickness |